Induction of a ragweed-specific allergic state in Ir-gene-restricted nonresponder mice.
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چکیده
منابع مشابه
Induction of a ragweed-specific allergic state in Ir-gene-restricted nonresponder mice
Mice of the inbred strains, C57BL/6 and C57BL/10 (H-2b), are genetically incapable of developing IgE antibody responses to ragweed pollen extract (RE) or its dinitrophenylated derivative, DNP-RE. This nonresponsiveness has previously been thought to reflect the absence of a relevant H-2-linked Ir genes controlling responses of inbred mice to these antigens. However, pretreatment of H-2b mice wi...
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A series of recent experiments from our laboratory have focused on the demonstration and characterization of a relatively IgE class-specific, nonantigen-specific, cellular suppressor mechanism involved in the murine IgE antibody response to allergens not controlled by H-2-1inked immune response (Ir) genes (1, 2). Such a suppressor T-cell mechanism was initially demonstrated indirectly by admini...
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1. The interactions between ragweed pollen and the saliva from ragweed-sensitive and non-sensitive humans have been examined. A number of morphological changes of the pollen grains take place under the conditions of the incubation. Of these changes, two occur only with incubation in allergic saliva and one occurs with the use of ‘inflammatory’ saliva, allergic or non-allergic. 2. The two change...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1977
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.146.1.302